Regulators of regulatory pathway: Metabolic pathways

All displayed regulators are experimentally validated.


Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0215 experimental ETAE_1202 (ugd) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 1306603..1307769 (+) 502611067 ETAE_0886 (esrB) promoter (↑)
REG0220 experimental ETAE_2787 (guaB) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 2925310..2926776 (-) 502612646 ETAE_0886 (esrB) promoter (↑)
REG0223 experimental ETAE_0659 (aceE) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 731608..734271 (+) 502610523 ETAE_0886 (esrB) promoter (↑)
REG0334 experimental PSA3335_RS05390 (iaaM) T6SS01041 insolico protein IAA regulatory pathway Pseudomonas savastanoi pv. savastanoi NCPPB 3335 chromosome (NZ_CP008742) 1090961..1092634 (-) 488619197 The transcript levels of vgrG (↓)
REG0191 experimental YPK_1551 (RovM) T6SS00260 experimental protein (p)ppGpp regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1713682..1714884 (-) 499506038 T6SS-4 promoter region (↓)
REG0106 experimental vp2049 (Thymidylate kinase, Tmk) T6SS00043 experimental protein Unknown Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2150113..2150745 (-) 28898823 T6SS1 (VgrG1) expression and secretion (↓)
REG0096 experimental PSPTO_RS08845 (relA) T6SS00041 insolico; T6SS00042 experimental protein (p)ppGpp regulatory pathway Pseudomonas syringae pv. tomato str. DC3000 chromosome (NC_004578) 1863879..1866122 (+) 494457621 T6SS transcripts (↓)
REG0148 experimental PSYR_RS19090 (relA) T6SS00086 experimental protein (p)ppGpp regulatory pathway Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 4380642..4382885 (-) 499587809 T6SS transcripts (↓)
REG0187 experimental YPK_3449 (RelA) T6SS00260 experimental protein (p)ppGpp regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 3783755..3785989 (-) 488138165 YPK_1551 (RovM) (↓); YPK_1876 (RovA) (↓)
REG0209 experimental ETAE_0743 (cdsA) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 820052..820909 (+) 502610607 ETAE_0886 (esrB) promoter (↑)
REG0013 experimental Y880_03649 (suhB) T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimental protein TCS regulatory pathway Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 3616623..3617438 (+) 489183406 Y880_02189 (gacA/uvrY) (↓)
REG0097 experimental PSPTO_RS00410 (spoT) T6SS00041 insolico; T6SS00042 experimental protein (p)ppGpp regulatory pathway Pseudomonas syringae pv. tomato str. DC3000 chromosome (NC_004578) 94805..96910 (-) 492171753 T6SS transcripts (↓)
REG0149 experimental PSYR_RS01070 (spoT) T6SS00086 experimental protein (p)ppGpp regulatory pathway Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 223004..225109 (-) 489499092 T6SS transcripts (↓)
REG0035 experimental GPY04_RS07700 (chiA1) T6SS01168 experimental protein ChiS-induced regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) 1709613..1712153 (-) 446755770 GPY04_RS01040 (ChiS) (↓)
REG0224 experimental ETAE_2773 (mtnN) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 2910743..2911441 (+) 502612632 ETAE_0886 (esrB) promoter (↑)
REG0245 experimental ETAE_3098 (PepA) T6SS00372 experimental protein Transcription regulator Edwardsiella tarda EIB202 chromosome (NC_013508) 3260322..3261833 (+) 502612947 ETAE_0886 (esrB) promoter (↑)
REG0210 experimental ETAE_2082 (pyrF) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 2196136..2196858 (-) 502611934 ETAE_0886 (esrB) promoter (↑)
REG0208 experimental ETAE_0154 (hemB) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 159867..160889 (+) 502610017 ETAE_0886 (esrB) promoter (↑)
REG0211 experimental ETAE_1096 (dapA) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 1194778..1195659 (+) 502610962 ETAE_0886 (esrB) promoter (↑)
REG0229 experimental ETAE_3449 (tpiA) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 3637381..3638145 (+) 502613286 ETAE_0886 (esrB) promoter (↓)
REG0218 experimental ETAE_0358 (purA) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 403538..404836 (+) 502610221 ETAE_0886 (esrB) promoter (↑)
REG0233 experimental ETAE_0695 (mrcB) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 766885..769368 (+) 502610560 ETAE_0886 (esrB) promoter (↓)
REG0281 experimental V12G01_02325 (HP) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000004) 115263..116411 (+) 91190993 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0302 experimental VCA1552_RS12925 (cya) T6SS01112 experimental protein QS regulatory pathway; cAMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2747346..2749877 (-) 447072406 VCA1552_RS12025 (crp) (↓)
REG0298 experimental VCA1552_RS01665 (LuxS) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 319588..320106 (+) 447052971 Hcp expression and secretion (↓)
REG0098 experimental PSPTO_RS04545 (fpRel) T6SS00041 insolico; T6SS00042 experimental protein (p)ppGpp regulatory pathway Pseudomonas syringae pv. tomato str. DC3000 chromosome (NC_004578) 927082..927900 (+) 499415849 T6SS transcripts (↓)
REG0066 experimental PA3476 (rhlI) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889139..3889744 (-) 15598672 PA3477 (RhlR) (↓)
REG0327 experimental WQ49_05060 (cepI) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 547435..548043 (+) 815852485 T6SS expression (↓)
REG0335 experimental PSA3335_RS05385 (iaaH) T6SS01041 insolico protein IAA regulatory pathway Pseudomonas savastanoi pv. savastanoi NCPPB 3335 chromosome (NZ_CP008742) 1089578..1090918 (-) 488619198 The transcript levels of vgrG (↓)
REG0093 experimental ECA_RS00520 (expI) T6SS00040 experimental protein QS regulatory pathway Pectobacterium atrosepticum SCRI1043 chromosome (NC_004547) 125689..126339 (+) 499404281 T6SS transcripts (ECA4275[hcp1], ECA3428[hcp2] and ECA2866[hcp3]) (↓)
REG0197 experimental YPK_RS08350 (ypsI) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1838406..1839050 (-) 501053391 T6SS transcripts (↓)
REG0198 experimental YPK_RS03970 (ytbI) T6SS00256 insolico; T6SS00260 experimental protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 901200..901850 (-) 488144695 T6SS transcripts (↓); T6SS4 transcripts and hcp secretion (↓)
REG0322 experimental GT391_RS06405 (expI) T6SS01170 experimental protein QS regulatory pathway Pectobacterium brasiliense strain 1692 chromosome (NZ_CP047495) 1436931..1437581 (-) 497970044 GT391_RS06470 (expR1) (↓)
REG0121 experimental CV_RS23145 (CviI) T6SS00049 insolico protein QS regulatory pathway Chromobacterium violaceum ATCC 12472 chromosome (NC_005085) 4426967..4427620 (-) 499450174 CV_RS20220 (CviR) (↓)
REG0370 experimental ACX60_RS11355 (racK) T6SS01046 experimental protein Environmental signal Acinetobacter baumannii strain ATCC 17978 chromosome (NZ_CP012004) 2382673..2383965 (+) WP_000769882.1 ACX60_RS00605 (Tse4) (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0215 experimental ETAE_1202 (ugd) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 1306603..1307769 (+) 502611067 ETAE_0886 (esrB) promoter (↑)
REG0220 experimental ETAE_2787 (guaB) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 2925310..2926776 (-) 502612646 ETAE_0886 (esrB) promoter (↑)
REG0223 experimental ETAE_0659 (aceE) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 731608..734271 (+) 502610523 ETAE_0886 (esrB) promoter (↑)
REG0334 experimental PSA3335_RS05390 (iaaM) T6SS01041 insolico protein IAA regulatory pathway Pseudomonas savastanoi pv. savastanoi NCPPB 3335 chromosome (NZ_CP008742) 1090961..1092634 (-) 488619197 The transcript levels of vgrG (↓)
REG0191 experimental YPK_1551 (RovM) T6SS00260 experimental protein (p)ppGpp regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1713682..1714884 (-) 499506038 T6SS-4 promoter region (↓)
REG0106 experimental vp2049 (Thymidylate kinase, Tmk) T6SS00043 experimental protein Unknown Vibrio parahaemolyticus RIMD 2210633 chromosome (NC_004603) 2150113..2150745 (-) 28898823 T6SS1 (VgrG1) expression and secretion (↓)
REG0096 experimental PSPTO_RS08845 (relA) T6SS00041 insolico; T6SS00042 experimental protein (p)ppGpp regulatory pathway Pseudomonas syringae pv. tomato str. DC3000 chromosome (NC_004578) 1863879..1866122 (+) 494457621 T6SS transcripts (↓)
REG0148 experimental PSYR_RS19090 (relA) T6SS00086 experimental protein (p)ppGpp regulatory pathway Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 4380642..4382885 (-) 499587809 T6SS transcripts (↓)
REG0187 experimental YPK_3449 (RelA) T6SS00260 experimental protein (p)ppGpp regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 3783755..3785989 (-) 488138165 YPK_1551 (RovM) (↓); YPK_1876 (RovA) (↓)
REG0209 experimental ETAE_0743 (cdsA) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 820052..820909 (+) 502610607 ETAE_0886 (esrB) promoter (↑)
REG0013 experimental Y880_03649 (suhB) T6SS01211 experimental; T6SS01212 experimental; T6SS01213 experimental protein TCS regulatory pathway Pseudomonas aeruginosa PAK chromosome (NZ_CP020659) 3616623..3617438 (+) 489183406 Y880_02189 (gacA/uvrY) (↓)
REG0097 experimental PSPTO_RS00410 (spoT) T6SS00041 insolico; T6SS00042 experimental protein (p)ppGpp regulatory pathway Pseudomonas syringae pv. tomato str. DC3000 chromosome (NC_004578) 94805..96910 (-) 492171753 T6SS transcripts (↓)
REG0149 experimental PSYR_RS01070 (spoT) T6SS00086 experimental protein (p)ppGpp regulatory pathway Pseudomonas syringae pv. syringae B728a chromosome (NC_007005) 223004..225109 (-) 489499092 T6SS transcripts (↓)
REG0035 experimental GPY04_RS07700 (chiA1) T6SS01168 experimental protein ChiS-induced regulatory pathway Vibrio cholerae C6706 chromosome (NZ_CP046844) 1709613..1712153 (-) 446755770 GPY04_RS01040 (ChiS) (↓)
REG0224 experimental ETAE_2773 (mtnN) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 2910743..2911441 (+) 502612632 ETAE_0886 (esrB) promoter (↑)
REG0245 experimental ETAE_3098 (PepA) T6SS00372 experimental protein Transcription regulator Edwardsiella tarda EIB202 chromosome (NC_013508) 3260322..3261833 (+) 502612947 ETAE_0886 (esrB) promoter (↑)
REG0210 experimental ETAE_2082 (pyrF) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 2196136..2196858 (-) 502611934 ETAE_0886 (esrB) promoter (↑)
REG0208 experimental ETAE_0154 (hemB) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 159867..160889 (+) 502610017 ETAE_0886 (esrB) promoter (↑)
REG0211 experimental ETAE_1096 (dapA) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 1194778..1195659 (+) 502610962 ETAE_0886 (esrB) promoter (↑)
REG0229 experimental ETAE_3449 (tpiA) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 3637381..3638145 (+) 502613286 ETAE_0886 (esrB) promoter (↓)
REG0218 experimental ETAE_0358 (purA) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 403538..404836 (+) 502610221 ETAE_0886 (esrB) promoter (↑)
REG0233 experimental ETAE_0695 (mrcB) T6SS00372 experimental protein TCS regulatory pathway Edwardsiella tarda EIB202 chromosome (NC_013508) 766885..769368 (+) 502610560 ETAE_0886 (esrB) promoter (↓)
REG0281 experimental V12G01_02325 (HP) T6SS00939 experimental protein QS regulatory pathway Vibrio alginolyticus 12G01 chromosome (AAPS01000004) 115263..116411 (+) 91190993 V12G01-21538 (luxR) promoter; V12G01-14830 (aphA) promoter
REG0302 experimental VCA1552_RS12925 (cya) T6SS01112 experimental protein QS regulatory pathway; cAMP regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 2747346..2749877 (-) 447072406 VCA1552_RS12025 (crp) (↓)
REG0298 experimental VCA1552_RS01665 (LuxS) T6SS01112 experimental protein QS regulatory pathway Vibrio cholerae strain A1552 chromosome (NZ_CP024867) 319588..320106 (+) 447052971 Hcp expression and secretion (↓)
REG0098 experimental PSPTO_RS04545 (fpRel) T6SS00041 insolico; T6SS00042 experimental protein (p)ppGpp regulatory pathway Pseudomonas syringae pv. tomato str. DC3000 chromosome (NC_004578) 927082..927900 (+) 499415849 T6SS transcripts (↓)
REG0066 experimental PA3476 (rhlI) T6SS00004 experimental protein QS regulatory pathway Pseudomonas aeruginosa PAO1 chromosome (NC_002516) 3889139..3889744 (-) 15598672 PA3477 (RhlR) (↓)
REG0327 experimental WQ49_05060 (cepI) T6SS01276 experimental protein QS regulatory pathway Burkholderia cenocepacia strain K56-2 chromosome (LAUA01000002) 547435..548043 (+) 815852485 T6SS expression (↓)
REG0335 experimental PSA3335_RS05385 (iaaH) T6SS01041 insolico protein IAA regulatory pathway Pseudomonas savastanoi pv. savastanoi NCPPB 3335 chromosome (NZ_CP008742) 1089578..1090918 (-) 488619198 The transcript levels of vgrG (↓)
REG0093 experimental ECA_RS00520 (expI) T6SS00040 experimental protein QS regulatory pathway Pectobacterium atrosepticum SCRI1043 chromosome (NC_004547) 125689..126339 (+) 499404281 T6SS transcripts (ECA4275[hcp1], ECA3428[hcp2] and ECA2866[hcp3]) (↓)
REG0197 experimental YPK_RS08350 (ypsI) T6SS00256 insolico protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 1838406..1839050 (-) 501053391 T6SS transcripts (↓)
REG0198 experimental YPK_RS03970 (ytbI) T6SS00256 insolico; T6SS00260 experimental protein QS regulatory pathway Yersinia pseudotuberculosis YPIII chromosome (NC_010465) 901200..901850 (-) 488144695 T6SS transcripts (↓); T6SS4 transcripts and hcp secretion (↓)
REG0322 experimental GT391_RS06405 (expI) T6SS01170 experimental protein QS regulatory pathway Pectobacterium brasiliense strain 1692 chromosome (NZ_CP047495) 1436931..1437581 (-) 497970044 GT391_RS06470 (expR1) (↓)
REG0121 experimental CV_RS23145 (CviI) T6SS00049 insolico protein QS regulatory pathway Chromobacterium violaceum ATCC 12472 chromosome (NC_005085) 4426967..4427620 (-) 499450174 CV_RS20220 (CviR) (↓)
REG0370 experimental ACX60_RS11355 (racK) T6SS01046 experimental protein Environmental signal Acinetobacter baumannii strain ATCC 17978 chromosome (NZ_CP012004) 2382673..2383965 (+) WP_000769882.1 ACX60_RS00605 (Tse4) (↓)

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
Regulator ID Locus tag (Gene) Related T6SS Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)